Stacks Image 3267
Stacks Image 3467
Funding administered by Dr Clare Rusbridge, Part Two

Click on the links below for more information

Stacks Image 3469
Backwards
Forwards
Stacks Image 857
Close

2000 - 2003
unfunded.
Aims: to establish that SM was inherited using pedigree analysis. Pedigrees were collected and a genealogy database was set up with SM affected dogs and their ancestors.

Backwards
Forwards
2004  DNA Collection and phenotype clarificatio


i) Boehringer Ingelheim Limited (manufacturers of Vetmedin®) funded the cost of a diagnostic test to identify macrothrombocytosis in Cavaliers that belonged to UK Cavalier Club Members. The left over blood was stored for DNA extraction. This was in conjunction with the Club’s Heart/Eye Clinics organised by the Cavalier Club

ii) UK DNA Archive for Companion Animals undertook the considerable task DNA extraction and storing of for over 500 blood samples with an estimated cost of £10,000

iii) $2000 (Australian) received from the CKCS Club of Victoria. – these funds were used for a computer tomography study of the caudal fossa in CKCS with and without Chiari malformation and syringomyelia. The results of this pilot study will be used towards further research in the future.

Backwards
Forwards
Close


2005 Genome Research
iv) $8,000 from the Cavalier Health Foundation  Grant #104
(
Scroll down the page to see all the grants) (USA) for the  “Study of the Successful Collection and Archiving of DNA from Cavalier King Charles Spaniels, Enabling a Genome Scan to be performed”. Dr Clare Rusbridge; Penny Knowler, Dr Berge A Minassian, Dr Guy A. Rouleau, Dr Diane Shelton.

v) $1,000 from
Christi Scarpino who owns a Boston terrier called Hope diagnosed with syringomyelia.  Christi used an extremely imaginative array of fundraising ideas including selling cherished collectables from Boston terrier lovers on EBay!

vi) $450
Kendall Barker also from sales from EBay.

vii) Archiving and extraction of DNA for over 200 dogs (total cost estimated at about $8,000).  Funded by
University of Utrecht with thanks to Dr P Mandigers and Prof. J Rothuizen.

viii) £575 gross was raised by the sale of the DVDs made by
Penny Knowler of the Lecture and Q & A on Syringomyelia by C Rusbridge to the UK Cavalier Club, Wood Green Animal Shelter, Cambs, UK.


Backwards
Forwards
2007  Phenotypic Information

xiii) $1,250 from CavalierTalk and Cavalier Connection Members led by
Bruce Hassig with the aim of sponsoring  the cost of MRI for dogs in the USA

xiv) $500 consisting of matched donations from
David Harwood, Sandy Smith, Carol Fowler and Gerri Prior Carter in addition to the proceeds of sales of the  Syringomyelia 2007 symposia double CD produced by Karlin Lillington (available from Cafepress - includes all the lectures and Q & A sessions). These funds were also to sponsor the cost of MRI for dogs in the USA

xv) €800 from
French Cavalier Club (FCKC) founded by Isabelle Barthes

xvi) $8,000 from the “
For the Love of Ollie Fund” (FTLO) (pioneered by Sandy Smith) and in this instance dedicated towards research into Chiari malformation in the Griffon Bruxellois

xvii) $5,000
Frank and Lee Pieterse – dedicated towards research into Chiari malformation in the Griffon Bruxellois.

xviii) £3,000 gross sale from 200 additional printed copies of
Dr Rusbridge’s Doctoral Thesis with special thanks to Marselle Stout for her help in the USA and Carol Fowler in the UK.
Backwards
Forwards
2007  Phenotypic Information

xiii) $1,250 from CavalierTalk and Cavalier Connection Members led by
Bruce Hassig with the aim of sponsoring  the cost of MRI for dogs in the USA

xiv) $500 consisting of matched donations from
David Harwood, Sandy Smith, Carol Fowler and Gerri Prior Carter in addition to the proceeds of sales of the  Syringomyelia 2007 symposia double CD produced by Karlin Lillington (available from Cafepress - includes all the lectures and Q & A sessions). These funds were also to sponsor the cost of MRI for dogs in the USA

xv) €800 from
French Cavalier Club (FCKC) founded by Isabelle Barthes

xvi) $8,000 from the “
For the Love of Ollie Fund” (FTLO) (pioneered by Sandy Smith) and in this instance dedicated towards research into Chiari malformation in the Griffon Bruxellois

xvii) $5,000
Frank and Lee Pieterse – dedicated towards research into Chiari malformation in the Griffon Bruxellois.

xviii) £3,000 gross sale from 200 additional printed copies of
Dr Rusbridge’s Doctoral Thesis with special thanks to Marselle Stout for her help in the USA and Carol Fowler in the UK.
Backwards
Forwards
2008

xix) $86,100 Grant # 954: American Kennel Club Health Foundation and sponsored by ACKCSC and The Cavalier Club USA:

Identification of genes causing Chiari- like Malformation with Syringomyelia in the Cavalier King Charles Spaniel. Principal Investigator Dr. Zoha Kibar, University of Montreal (MU) Canada. Co-investigators: Dr Guy Rouleau, and Dr Marie-Pierre Dube (MU), Dr Clare Rusbridge and Penny Knowler, SLVC, UK

xx) $104,000. Grant #1004. American Kennel Club Health Foundation with matching funds American Brussels Griffon Association, Griffon Bruxellois Breeders Association, Griffon Bruxellois Club of Victoria: Syringomyelia in the Brussels Griffon (Griffon Bruxellois): Magnetic Resonance Imaging Findings, Clinicopathology, and Prevalence. Principal Investigators: Dr Marc Kent and Dr Simon Platt, Georgia University, USA Co-investigators: Dr Scott Schatzberg, (GU) Dr Clare Rusbridge and Penny Knowler (SLVC, UK)

xxi) £1,575 Plant Sale ‘Cavalier Friends’ organised by Sue Robinson and friends. This provides Bursaries for research into CM/SM by young graduates. The first project awarded has been to Colin Driver MRCVS , Royal Veterinary College into his study on Comparison between skull and brain volume in syringomyelia affected and unaffected Cavaliers

xxii) £750 Grant from Cavalier Club UK: Cerebrospinal fluid abnormalities in Syringomyelia. Investigation by Dr C Rusbridge (SLVC) and Prof N Jeffery (Cambridge)

xxiii) £2,500 Griffon Bruxellois Club 1897 (ring-fenced for UK dogs)

xxiv) €1,075 French Cavalier Club (FCKC) (Isabelle Barthes)

xxv) £100 each from Joy Denman and Carol Fowler (in lieu of Health Prize which UK CKCS Club rejected)
Backwards
Forwards
2009

xxvi) $100 from Celestial Designs - this donation was used towards buying buccal swabs for SM DNA Collection


xxvii) £380 via Carol Fowler who had received numerous donations towards research following airing of the documentary “Pedigree Dog Exposed” This donation funded MRI screening.


xxviii) $9,500 from the FTLO Fund. This donation has been be used to subsidize MRI screening of Canadian dogs over 6 years.


xxix) £300 from Cavalier Friends to continue the Student Bursary scheme.


xxx) £583.22 from Griffon Bruxellois Club 1897 donation from


xxxi) £300 West Chiltington Cavalier Club xxxii) £100 donation from Gerri Pryor Carter (USA)

Backwards
Forwards
Stacks Image 858
2010
xxxiii) £250 donation from Mr K Ashley (UK)
xxxiv)£300 Cavalier Friends (Sue Robinson) for the Bursary Fund
xxxv) £150 running total so far from sales of very popular Lavender Bags. These are made by Lucy Alboni who grows the lavender herself in the garden
xxxvi) $171 April and Jim Gregg (Celestial Designs) from the sale of Rainbow Paws cards in memory of beloved Sage.

In February,
Karlin Lillington launched an initiative from CavalierTalk members
http://www.rupertsfund.com/Ruperts_Fund.html
Rupert’s Fund is paid directly to ‘SM DNA Research’ but is ring-fenced to to create a rolling fund to MRI older cavaliers, age 6+ which provides information and DNA for
  • Canadian genome research, aimed at finding the causative genes for Syringomyelia
  • Estimated Breeding Values (EBVs), which will enable cavalier breeders to select the most genetically appropriate         mates to help reduce incidence of syringomyelia in the breed.
Current total of fund and details of the many varied and ingenious initiatives to raise money and enthusiastic support can be found on the Cavalier Talk website http://www.cavaliertalk.com/forums/forumdisplay.php?72-Rupert-s-Fund Running total for 7months is an amazing £7,000  and demonstrates the hard work of fund raisers like Nicki Hughes, Tania Ledger , Karen Benard, and others

xxxvii)
£2,000 The Cavalier Club donation SM DNA Research to fund MRIs for cavaliers over 6 years of age
xxxviii) £500
Griffon Bruxellois Club (UK) proceeds from Mr Ogden’s spectacular slimarathon
xxxix)£180
Griffon Bruxellois Breeders Association – auction of Lee Pieterse’s lovely griffon pewter figurine.
The Club have also agreed to pay for members MRI scans to be read by Clare to ensure consistency for the genome research.
xxxx) £150 Griffon Bruxellois Club – donation for seminar

Stacks Image 859
In June, Rachael Harvey launched her website ‘Friends of Lola’ in support of Griffon Bruxellois and other Breeds with CMSM.
For details see 
http://www.friends-of-lola.com/index.html .
She kindly agreed to include fundraising to pay for MRIs to help find the causal gene/s for Chiari-like Malformation.
Details can be found on the website of the Donations include those from Russia,
Australia , from the Griffon Bruxellois Club’s Garden Party and from
sales of artwork from KC Pet Collectables . Running total for September is £1276.43
 
£345 was raised from the Auction at the Griffon Bruxellois Club Garden Party in June.
Backwards
Forwards
2011

xxxxi)
Rupert's Fund achieved an amazing target of £11,130 for 1/1/1011.  This money is ring-fenced to pay for MRIs of asymptomatic dogs over 5/6 years of age -details on the website. Number of dogs scanned in 1 year =29.
For update on total donations during the years please check out the website.
 
xxxxii) £420 Another generous donation from the
West Chiltington Cavalier Club Sponsored walk. This money will be used to fund MRIs not covered by Rupert's Fund or Friends of Lola Fund.
 
xxxxiv)
Griffon Bruxellois Club 1897 donation for £3,000 per year for the next 3 years  to pay for Griffon MRIs to support the genome research. This huge contibution demonstrates a major committment towards improving the health and welfare of their breed.
Backwards
Forwards
Money sent to Montreal University for our genome research

Dr Guy Rouleau, MD PhD FRCP(C) Director, Ste-Justine Hospital Research Center and The Center for the Study of Brain Diseases, FAO Dr Zoha Kibar, 3175 Cote-Ste-Catherine, Room A711, Montreal, QC H3T 1C5 Canada.). The money was dedicated to canine CM/SM Research. Please notify Dr Clare Rusbridge of any donation for our records.

2008
$3,500 The UK CKCS Club
$1,000 Cavalier Club of Canada - including DVD sales of Clare' seminar to the Club.

2009
Ann Conway Trust Grant
$500 Cavalier Club of Canada -This sum was used to pay for saliva mops for the Canadian 'over 6 year project'.
2010
$1,000 Cavalier Club of Canada.
Initiatives supported by SM DNA Research Fund.
Backwards
Forwards
Initiatives supported by SM DNA Research Fund.

Our priority has been to fund MRIs and other phenotypic tests for dogs which have been identified to enhance the genome research. These have included Cavaliers, Griffon Bruxellois, King Charles Spaniels and a Havanese. Countries involved include UK, France, Netherlands, Finland, Australia, New Zealand, USA and Canada. Most recently we have been focusing on CKCS ‘controls’ over 6 years that do NOT have SM.

Sponsorship of Syringomyelia 2007 Conference ‘Ask the Experts’ session
Collaboration with Dr Sarah Blott to determine heritability of CM/SM

BVA/KC scheme for MRI screening protocol – funding of the preliminary meeting.
DNA buccal swab collection – purchase of Genotek saliva kits and postage.

Student Bursaries investigating pathogenesis of Syringomyelia: Colin Driver (Royal Veterinary College) Samantha McGuiness (Bristol University Vet school)